S.E.M.I. – Side Effects May Include...
S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!
Last Updated: 3/13/2026
| Steam Price | $7.99 |
| Release Date | 1/23/2026 |
| Developer | Two Horn Unicorn |
| Publisher | Two Horn Unicorn |
| Steam App Id | 3957560 |
S.E.M.I. – Side Effects May Include...
S.E.M.I. is a single-player and co-op action platformer with puzzle elements. Play as patients of an unusual clinic, take experimental drugs, interfere with each other, and be ready for chaos and unpredictable side effects!
Last Updated: 3/13/2026
- Windows
- Mac
- Linux
About S.E.M.I. – Side Effects May Include...
S.E.M.I. – Side Effects May Include... is an Indie, Action, and Early Access game developed by Two Horn Unicorn. On 1/23/2026, it was released on the Steam Store by Two Horn Unicorn.
It can be played and ran on Windows systems. At the moment, there is no confirmed information regarding Steam Deck support for this game.
It also supports 9 languanges in-game including English, Russian, French, German, and Spanish (Spain). Each language comes with varying levels of support for the in-game interface, audio, and fully translated subtitles.
According to Steam’s category system, S.E.M.I. – Side Effects May Include... supports the following features:
- Custom Volume Controls
- Family Sharing
- Single-player
- Co-op
- Online Co-op
- Multi-player
- Full controller support
- Steam Achievements
- Stereo Sound
- Playable without Timed Input
- Surround Sound
From the Steam community, S.E.M.I. – Side Effects May Include... has been tagged with the following user tags:
- Character Customization
- Action Roguelike
- Psychological
- Third Person
- Multiplayer
- Surreal
- Platformer
- Stylized
- Puzzle
- Beat 'em up
- 3D
- Co-op
- Comedy
- Logic
- Funny
- Indie
- Early Access
- Online Co-Op
- Action
- Singleplayer
- Physics
Media & Sceenshots
Watch the featured video for S.E.M.I. – Side Effects May Include... and see the latest screenshots from the Steam Store.
S.E.M.I. – Side Effects May Include... DLC
S.E.M.I. – Side Effects May Include... has 1 downloadable add-on available for purchase on Steam which is S.E.M.I. – Side Effects May Include: Digital Artbook.
| Image | Name | Type | Release Date | Actions |
|---|---|---|---|---|
 | S.E.M.I. – Side Effects May Include: Digital Artbook | DLC | 1/20/2026 | Steam Charts |
S.E.M.I. – Side Effects May Include... has 2 related apps available for download from the Steam store.
| Image | Name | Type | Release Date | Actions |
|---|---|---|---|---|
 | S.E.M.I. – Side Effects May Include Christmas Soundtrack | Music | 1/12/2026 | Steam Charts |
 | S.E.M.I. – Side Effects May Include Soundtrack | Music | 1/12/2026 | Steam Charts |
Related Packages
S.E.M.I. – Side Effects May Include... is referenced by 1 package in the Steam Store. A package (or sub) is simply an item that can be purchased on Steam.
| Name | Price | Actions |
|---|---|---|
| S.E.M.I. – Side Effects May Include | $6.79 | View |
Supported Languages and Localizations
S.E.M.I. – Side Effects May Include... is available in 9 different languages with varying levels of support for the in-game interface, audio, and fully translated subtitles.
| Name | Interface | Audio | Subtitles |
|---|---|---|---|
| English | Yes | No | No |
| Russian | Yes | No | No |
| French | Yes | No | No |
| German | Yes | No | No |
| Spanish (Spain) | Yes | No | No |
| Chinese (Simplified) | Yes | No | No |
| Portuguese-Brazil | Yes | No | No |
| Japanese | Yes | No | No |
| Korean | Yes | No | No |
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Soures & References
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S.E.M.I. – Side Effects May Include... data has been sourced from:
- Valve Corporation. (2026, March 13). S.E.M.I. – Side Effects May Include... on Steam. Steam Store.
- Valve Corporation. (2026, March 13). S.E.M.I. – Side Effects May Include.... Steam Community Hub.